Open Postdoctoral Position

Molecular Mechanisms of Synaptic transmission and Impact on Neuronal Circuit Output

Samuel Young Laboratory

There is an open post-doctoral position in the laboratory of Samuel Young at the University of Iowa Carver College of Medicine, Iowa City, IA. https://young.lab.uiowa.edu/Twitter @samyounglab  The Young laboratory is focused on the fundamental question: How do synapses enable neuronal circuits to transmit a wide diversity of information?  Outcomes from our work will define the molecular principles that govern how synaptic properties drive neuronal circuit output, which underpins organism behavior.

We use the calyx of Held/MNTB synapse. This model system which provides unparalleled opportunities to gain insights into the presynaptic mechanisms that support the initial stages of auditory processing. The laboratory uses an integrated approach that centers on using novel viral vector technology, electrophysiological and biophysical methods, biochemistry, light and electron microscopy techniques in conjunction with transgenic mice. Two major areas of research focus are

Presynaptic release mechanisms for fast auditory signaling.We seek to understand the mechanisms of synaptic vesicle release and recovery that permit the accurate encoding of sound over wide dynamic ranges over varying times scales. We aim to define the molecular mechanisms that ensure availability of release competent SVs throughout a wide range of AP firing rates and their impact on sound localization.

Presynaptic CaV2 channel function.The goal of this project is to reveal the molecular mechanisms that regulate presynaptic CaV2 channel function and their role in regulating synaptic transmission throughout neuronal circuit development in the mammalian central nervous system

Candidates must have a PhD in a related scientific discipline and at least one first author publication. Expertise in any of the approaches used in the laboratory are preferred. Interested candidates should submit their Curriculum Vitaea cover letter and complete contact information for at least three references to Dr. Samuel Young at Samuel-m-young@uiowa.edu

Please include Calyx of Held postdoc in the subject line.

The Young laboratory is affiliated with the Department of Anatomy and Cell Biology at the University of Iowa and located within the Pappajohn BioMedical Discovery Building. Dr. Young is a member of the Iowa Neuroscience Institute https://medicine.uiowa.edu/iowaneuroscience/, Pappajohn Biomedical Institute https://medicine.uiowa.edu/pbi/, and has a joint appointment within the Department of Otolaryngology and is part of the Center for Auditory Regeneration and Deafness https://medicine.uiowa.edu/center-auditory-regeneration-and-deafness. In addition, The University of Iowa provides an outstanding intellectual environment and access to a wide range of cutting edge technologies which gives individual multiple opportunities to take advantage of the diverse knowledge, techniques expertise of the local community and incorporate into their research project.  Finally, Dr. Young is committed to the career development of trainees as previous postdoctoral fellows have successfully continued their careers in academia and industry.

Iowa City is a vibrant mid-sized city that perennially ranks in the top 10 as a "Best Place to Live" http://www.iowacityareadevelopment.com/live/rankings.aspx). It is the first UNESCO City of Literature in the U.S. and hosts a wide variety of cultural, artistic, and sporting events year-round.

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